Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 240589..241185 Replicon chromosome
Accession NZ_CP116249
Organism Enterobacter roggenkampii strain 120063

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag KK030_RS01155 Protein ID WP_059363955.1
Coordinates 240883..241185 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID W7P674
Locus tag KK030_RS01150 Protein ID WP_021242718.1
Coordinates 240589..240876 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KK030_RS01145 (KK030_01145) 238961..240592 + 1632 WP_214573511.1 Na/Pi cotransporter family protein -
KK030_RS01150 (KK030_01150) 240589..240876 - 288 WP_021242718.1 putative addiction module antidote protein Antitoxin
KK030_RS01155 (KK030_01155) 240883..241185 - 303 WP_059363955.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KK030_RS01160 (KK030_01160) 241383..242255 + 873 WP_008503414.1 23S rRNA pseudouridine(2604) synthase RluF -
KK030_RS01165 (KK030_01165) 242256..242528 - 273 WP_059360216.1 DUF3811 domain-containing protein -
KK030_RS01170 (KK030_01170) 242579..243523 - 945 WP_023293551.1 ketopantoate/pantoate/pantothenate transporter PanS -
KK030_RS01175 (KK030_01175) 243629..245203 - 1575 WP_214573510.1 RNA repair transcriptional activator RtcR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-93)

Antitoxin

Uncharacterized protein HI1420

(3-89)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11360.10 Da        Isoelectric Point: 10.1771

>T268548 WP_059363955.1 NZ_CP116249:c241185-240883 [Enterobacter roggenkampii]
MKEIVQTESFRRWEQNLKDRRAKTIIASRLFRLANGLAGDVKPVGEGISELRIHFGPGYRIYFKDQGNYIIVLLCGGDKS
SQARDILMAKMLSNVSQSQE

Download         Length: 303 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10156.57 Da        Isoelectric Point: 6.4596

>AT268548 WP_021242718.1 NZ_CP116249:c240876-240589 [Enterobacter roggenkampii]
MHKLTPYDPANALVDDEEIAVFIADALETGDSTYIAKALGVVARAKGMSNISQQTGLSREQLYRSFSDKGNPTLKTTLAV
MKALGFGLTLKHAGD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W7P674

References