Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 109795..110420 Replicon plasmid unnamed2
Accession NZ_CP116243
Organism Escherichia coli strain 7.1994/NIST0056

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PH192_RS24390 Protein ID WP_000911333.1
Coordinates 110022..110420 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag PH192_RS24385 Protein ID WP_000450520.1
Coordinates 109795..110022 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH192_RS24380 (109153) 109153..109713 - 561 Protein_107 conjugative relaxase -
PH192_RS24385 (109795) 109795..110022 + 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin
PH192_RS24390 (110022) 110022..110420 + 399 WP_000911333.1 tRNA(fMet)-specific endonuclease VapC Toxin
PH192_RS24395 (110429) 110429..112582 - 2154 WP_000009325.1 type IV conjugative transfer system coupling protein TraD -
PH192_RS24400 (112835) 112835..113566 - 732 WP_000850422.1 conjugal transfer complement resistance protein TraT -
PH192_RS24405 (113580) 113580..114089 - 510 WP_000628107.1 conjugal transfer entry exclusion protein TraS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN / vat 1..148536 148536
- flank IS/Tn - - 108398..108901 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14919.19 Da        Isoelectric Point: 7.8605

>T268540 WP_000911333.1 NZ_CP116243:110022-110420 [Escherichia coli]
MLKFMLDTNICIFTMKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT268540 WP_000450520.1 NZ_CP116243:109795-110022 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References