Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 72612..73159 Replicon plasmid unnamed2
Accession NZ_CP116243
Organism Escherichia coli strain 7.1994/NIST0056

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag PH192_RS24180 Protein ID WP_097309154.1
Coordinates 72612..72890 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag PH192_RS24185 Protein ID WP_000079941.1
Coordinates 72890..73159 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH192_RS24150 (68876) 68876..69010 - 135 WP_249531455.1 hypothetical protein -
PH192_RS24155 (68970) 68970..69911 - 942 WP_001312841.1 3-deoxy-7-phosphoheptulonate synthase -
PH192_RS24160 (70092) 70092..70392 + 301 Protein_63 hypothetical protein -
PH192_RS24165 (70470) 70470..70817 - 348 WP_000142437.1 DUF6404 family protein -
PH192_RS24170 (71119) 71119..71601 - 483 WP_001311056.1 hypothetical protein -
PH192_RS24175 (71718) 71718..72566 - 849 WP_001058005.1 3'-5' exonuclease -
PH192_RS24180 (72612) 72612..72890 - 279 WP_097309154.1 type II toxin-antitoxin system toxin YacB Toxin
PH192_RS24185 (72890) 72890..73159 - 270 WP_000079941.1 type II toxin-antitoxin system antitoxin YacA Antitoxin
PH192_RS24190 (73681) 73681..74909 + 1229 WP_112030635.1 IS3-like element IS2 family transposase -
PH192_RS24195 (75106) 75106..76380 + 1275 WP_000489607.1 HlyD family secretion protein -
PH192_RS24200 (76487) 76487..76759 + 273 Protein_71 cysteine peptidase family C39 domain-containing protein -
PH192_RS24205 (76940) 76940..77926 + 987 Protein_72 IS4-like element IS421 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN / vat 1..148536 148536


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10799.42 Da        Isoelectric Point: 8.4615

>T268533 WP_097309154.1 NZ_CP116243:c72890-72612 [Escherichia coli]
MEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASNLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTVQKWP

Download         Length: 279 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT268533 WP_000079941.1 NZ_CP116243:c73159-72890 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References