Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4464277..4464902 Replicon chromosome
Accession NZ_CP116241
Organism Escherichia coli strain 7.1994/NIST0056

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag PH192_RS21625 Protein ID WP_000911329.1
Coordinates 4464504..4464902 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PH192_RS21620 Protein ID WP_000450524.1
Coordinates 4464277..4464504 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH192_RS21595 (4460079) 4460079..4460549 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
PH192_RS21600 (4460549) 4460549..4461121 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PH192_RS21605 (4461267) 4461267..4462145 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PH192_RS21610 (4462162) 4462162..4463196 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
PH192_RS21615 (4463409) 4463409..4464122 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PH192_RS21620 (4464277) 4464277..4464504 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PH192_RS21625 (4464504) 4464504..4464902 + 399 WP_000911329.1 type II toxin-antitoxin system VapC family toxin Toxin
PH192_RS21630 (4465049) 4465049..4465912 + 864 WP_001267498.1 neutral zinc metallopeptidase -
PH192_RS21635 (4465927) 4465927..4467942 + 2016 WP_028985187.1 tRNA cytosine(34) acetyltransferase TmcA -
PH192_RS21640 (4468016) 4468016..4468714 + 699 WP_000679812.1 esterase -
PH192_RS21645 (4468824) 4468824..4469024 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T268527 WP_000911329.1 NZ_CP116241:4464504-4464902 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT268527 WP_000450524.1 NZ_CP116241:4464277-4464504 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References