Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2531198..2531793 Replicon chromosome
Accession NZ_CP116241
Organism Escherichia coli strain 7.1994/NIST0056

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag PH192_RS12325 Protein ID WP_000239579.1
Coordinates 2531198..2531548 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag PH192_RS12330 Protein ID WP_001223208.1
Coordinates 2531542..2531793 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH192_RS12305 (2526644) 2526644..2527666 - 1023 WP_024251350.1 ABC transporter permease -
PH192_RS12310 (2527680) 2527680..2529182 - 1503 WP_000205810.1 sugar ABC transporter ATP-binding protein -
PH192_RS12315 (2529322) 2529322..2530278 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
PH192_RS12320 (2530588) 2530588..2531118 + 531 WP_097765918.1 inorganic diphosphatase -
PH192_RS12325 (2531198) 2531198..2531548 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
PH192_RS12330 (2531542) 2531542..2531793 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
PH192_RS12335 (2532006) 2532006..2532347 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
PH192_RS12340 (2532350) 2532350..2536129 - 3780 WP_033554239.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T268511 WP_000239579.1 NZ_CP116241:c2531548-2531198 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT268511 WP_001223208.1 NZ_CP116241:c2531793-2531542 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References