Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 1872093..1872930 Replicon chromosome
Accession NZ_CP116241
Organism Escherichia coli strain 7.1994/NIST0056

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag PH192_RS09225 Protein ID WP_000227784.1
Coordinates 1872388..1872930 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag PH192_RS09220 Protein ID WP_001297137.1
Coordinates 1872093..1872404 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH192_RS09195 (1867113) 1867113..1868060 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
PH192_RS09200 (1868082) 1868082..1870073 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
PH192_RS09205 (1870063) 1870063..1870677 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
PH192_RS09210 (1870677) 1870677..1871006 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
PH192_RS09215 (1871018) 1871018..1871908 + 891 WP_000971336.1 heme o synthase -
PH192_RS09220 (1872093) 1872093..1872404 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
PH192_RS09225 (1872388) 1872388..1872930 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
PH192_RS09230 (1872986) 1872986..1873921 - 936 WP_001297127.1 tetratricopeptide repeat protein -
PH192_RS09235 (1874329) 1874329..1875693 + 1365 WP_001000978.1 MFS transporter -
PH192_RS09240 (1875821) 1875821..1876312 - 492 WP_001138904.1 nucleotide binding protein YajQ -
PH192_RS09245 (1876480) 1876480..1877391 + 912 WP_000705874.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T268510 WP_000227784.1 NZ_CP116241:1872388-1872930 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT268510 WP_001297137.1 NZ_CP116241:1872093-1872404 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References