Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1838017..1838635 Replicon chromosome
Accession NZ_CP116241
Organism Escherichia coli strain 7.1994/NIST0056

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PH192_RS09055 Protein ID WP_001291435.1
Coordinates 1838417..1838635 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PH192_RS09050 Protein ID WP_000344800.1
Coordinates 1838017..1838391 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH192_RS09040 (1833106) 1833106..1834299 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PH192_RS09045 (1834322) 1834322..1837471 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PH192_RS09050 (1838017) 1838017..1838391 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PH192_RS09055 (1838417) 1838417..1838635 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PH192_RS09060 (1838806) 1838806..1839357 + 552 WP_000102564.1 maltose O-acetyltransferase -
PH192_RS09065 (1839473) 1839473..1839943 + 471 WP_000136192.1 YlaC family protein -
PH192_RS09070 (1840107) 1840107..1841657 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PH192_RS09075 (1841699) 1841699..1842052 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PH192_RS09085 (1842431) 1842431..1842742 + 312 WP_000409911.1 MGMT family protein -
PH192_RS09090 (1842773) 1842773..1843345 - 573 WP_271356475.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T268509 WP_001291435.1 NZ_CP116241:1838417-1838635 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT268509 WP_000344800.1 NZ_CP116241:1838017-1838391 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References