Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5735619..5736244 Replicon chromosome
Accession NZ_CP116239
Organism Pseudomonas sp. TUM22785

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag PI990_RS26085 Protein ID WP_184487482.1
Coordinates 5736062..5736244 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PI990_RS26080 Protein ID WP_184487483.1
Coordinates 5735619..5736026 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PI990_RS26070 (PI990_26070) 5733449..5734456 + 1008 WP_271658918.1 nucleoid-associated protein YejK -
PI990_RS26075 (PI990_26075) 5734515..5735450 - 936 WP_021220875.1 glutathione S-transferase family protein -
PI990_RS26080 (PI990_26080) 5735619..5736026 - 408 WP_184487483.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PI990_RS26085 (PI990_26085) 5736062..5736244 - 183 WP_184487482.1 type II toxin-antitoxin system HicA family toxin Toxin
PI990_RS26090 (PI990_26090) 5736398..5736697 - 300 WP_271658919.1 GIY-YIG nuclease family protein -
PI990_RS26095 (PI990_26095) 5736694..5737392 - 699 WP_271658920.1 glutathione S-transferase family protein -
PI990_RS26100 (PI990_26100) 5737483..5737953 - 471 WP_271658921.1 nuclear transport factor 2 family protein -
PI990_RS26105 (PI990_26105) 5738072..5739022 + 951 WP_271661357.1 helix-turn-helix domain-containing protein -
PI990_RS26110 (PI990_26110) 5739437..5740564 + 1128 WP_265170506.1 IS481 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6854.94 Da        Isoelectric Point: 10.4779

>T268500 WP_184487482.1 NZ_CP116239:c5736244-5736062 [Pseudomonas sp. TUM22785]
MRSREVIEKIKEDGWYEVEVKGSHHQFKHPNKPGRVTVPHPKSDLPIGTVRSILKQAGLL

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14439.26 Da        Isoelectric Point: 4.3752

>AT268500 WP_184487483.1 NZ_CP116239:c5736026-5735619 [Pseudomonas sp. TUM22785]
MKFPLVLHKDPDSDYGVTVPDVPGCFSAGATVAEALENVKEALALHFEGLVADGEALPQAQQIDVHIGNPDFAGGVWAVV
EFDVTPYLGKAVRFNATLPENLLQRIDERVSKDARYASRSGFLATAALRELSDAG

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References