Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1957756..1958216 Replicon chromosome
Accession NC_017522
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag CCDC5180_RS09175 Protein ID WP_003898996.1
Coordinates 1957968..1958216 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag CCDC5180_RS09170 Protein ID WP_003408528.1
Coordinates 1957756..1957968 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCDC5180_RS09155 1954234..1955421 - 1188 WP_003898992.1 nitrate transporter NarK -
CCDC5180_RS09160 1955708..1955992 + 285 WP_003408522.1 DUF1876 domain-containing protein -
CCDC5180_RS09165 1956006..1957688 - 1683 WP_003901239.1 SulP family inorganic anion transporter -
CCDC5180_RS09170 1957756..1957968 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CCDC5180_RS09175 1957968..1958216 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
CCDC5180_RS09180 1958224..1958961 + 738 WP_003898997.1 hypothetical protein -
CCDC5180_RS09185 1959055..1960755 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
CCDC5180_RS09190 1961040..1961442 - 403 Protein_1789 hypothetical protein -
CCDC5180_RS09195 1961432..1962043 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T26849 WP_003898996.1 NC_017522:1957968-1958216 [Mycobacterium tuberculosis CCDC5180]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T26849 NC_017522:1957968-1958216 [Mycobacterium tuberculosis CCDC5180]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT26849 WP_003408528.1 NC_017522:1957756-1957968 [Mycobacterium tuberculosis CCDC5180]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT26849 NC_017522:1957756-1957968 [Mycobacterium tuberculosis CCDC5180]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References