Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 20551..21742 Replicon chromosome
Accession NZ_CP116234
Organism Helicobacter pylori strain H390d

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag PHA49_RS00080 Protein ID WP_271330745.1
Coordinates 20978..21742 (+) Length 255 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag PHA49_RS00075 Protein ID WP_271330744.1
Coordinates 20551..20988 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA49_RS00060 (PHA49_00060) 17602..18147 + 546 Protein_10 TaqI-like C-terminal specificity domain-containing protein -
PHA49_RS00065 (PHA49_00065) 18148..18690 + 543 WP_271330743.1 hypothetical protein -
PHA49_RS00070 (PHA49_00070) 18701..20326 + 1626 WP_271331174.1 RNA-directed DNA polymerase -
PHA49_RS00075 (PHA49_00075) 20551..20988 + 438 WP_271330744.1 Panacea domain-containing protein Antitoxin
PHA49_RS00080 (PHA49_00080) 20978..21742 + 765 WP_271330745.1 hypothetical protein Toxin
PHA49_RS00085 (PHA49_00085) 21973..23160 - 1188 WP_271330746.1 transcription termination factor NusA -
PHA49_RS00090 (PHA49_00090) 23248..24408 - 1161 WP_271330747.1 aminotransferase class V-fold PLP-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(24-119)


Sequences

Toxin        


Download         Length: 255 a.a.        Molecular weight: 29864.10 Da        Isoelectric Point: 8.7873

>T268486 WP_271330745.1 NZ_CP116234:20978-21742 [Helicobacter pylori]
METKEEGKDKKLEKIIVLLCEEGDLSSQKDQIIKDLKEIYKGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLEDELNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLVFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSEEKKDKQENFFKKLIFWFNLIVIILFVFGFF
GELHIIQRLVSKYL

Download         Length: 765 bp

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 17202.33 Da        Isoelectric Point: 6.4926

>AT268486 WP_271330744.1 NZ_CP116234:20551-20988 [Helicobacter pylori]
MVNTLELAKYILKHSNKGLSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINCSIKKCNEKSYWDLVKESHKEDGAWHKSFREDRKEIISKDLIKQEAKQANGN

Download         Length: 438 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References