268485

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-HTH_37
Location 2424978..2425623 Replicon chromosome
Accession NZ_CP116231
Organism Fusobacterium nucleatum strain JD-Fn1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PGW91_RS11540 Protein ID WP_271333211.1
Coordinates 2424978..2425346 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag PGW91_RS11545 Protein ID WP_029492811.1
Coordinates 2425336..2425623 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGW91_RS11525 (PGW91_11525) 2421659..2423968 + 2310 WP_271333208.1 AAA family ATPase -
PGW91_RS11530 (PGW91_11530) 2424063..2424200 + 138 WP_271333209.1 hypothetical protein -
PGW91_RS11535 (PGW91_11535) 2424401..2424862 + 462 WP_271333210.1 hypothetical protein -
PGW91_RS11540 (PGW91_11540) 2424978..2425346 + 369 WP_271333211.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PGW91_RS11545 (PGW91_11545) 2425336..2425623 + 288 WP_029492811.1 helix-turn-helix domain-containing protein Antitoxin
PGW91_RS11550 (PGW91_11550) 2425646..2425966 + 321 WP_271333212.1 nucleotidyltransferase domain-containing protein -
PGW91_RS11555 (PGW91_11555) 2426031..2426249 + 219 WP_271333213.1 DUF6290 family protein -
PGW91_RS11560 (PGW91_11560) 2426289..2426831 - 543 WP_032847252.1 hypothetical protein -
PGW91_RS11565 (PGW91_11565) 2426858..2427364 - 507 WP_271333214.1 HAD family hydrolase -
PGW91_RS11570 (PGW91_11570) 2427374..2427946 - 573 WP_032833974.1 crossover junction endodeoxyribonuclease RuvC -
PGW91_RS11575 (PGW91_11575) 2427946..2428698 - 753 WP_032847258.1 MgtC/SapB family protein -
PGW91_RS11580 (PGW91_11580) 2428818..2429570 - 753 WP_032847260.1 SDR family oxidoreductase -
PGW91_RS11585 (PGW91_11585) 2429754..2430407 + 654 WP_238983103.1 Crp/Fnr family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(35-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-89)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 14752.33 Da        Isoelectric Point: 10.4222

>T268485 WP_271333211.1 NZ_CP116231:2424978-2425346 [Fusobacterium nucleatum]
MYKVGFYLKNGKSDIIEYLDKLKIKSEKSKEARIIRNKILSYIKSLELYGTRVGEPIVKHIEDNIWELRPLNNRIFFFYF
KDNKFILLHYFIKKTNKTPKKEIEEAKNRMNDFIARSDKNVK

Download         Length: 369 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.79 Da        Isoelectric Point: 5.1767

>AT268485 WP_029492811.1 NZ_CP116231:2425336-2425623 [Fusobacterium nucleatum]
MSNNEYLDFDDYFNDETKVSKEDKAIIELETLLIGKMIEIREKKGLTQRQLAELTGMKQPAIARLEKLQTIPHLTTLIKF
LTPLGYKLSIVPIEN

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References