Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-Axe/YoeB-RelB
Location 1982540..1983047 Replicon chromosome
Accession NZ_CP116231
Organism Fusobacterium nucleatum strain JD-Fn1

Toxin (Protein)


Gene name yoeB Uniprot ID U7TRZ4
Locus tag PGW91_RS09135 Protein ID WP_023037539.1
Coordinates 1982787..1983047 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID U7TRN8
Locus tag PGW91_RS09130 Protein ID WP_005892688.1
Coordinates 1982540..1982794 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGW91_RS09115 (PGW91_09115) 1979399..1979761 + 363 WP_271333008.1 Spx/MgsR family RNA polymerase-binding regulatory protein -
PGW91_RS09120 (PGW91_09120) 1979763..1981046 + 1284 WP_271333009.1 branched-chain amino acid transport system II carrier protein -
PGW91_RS09125 (PGW91_09125) 1981039..1982247 + 1209 WP_271333010.1 tyrosine--tRNA ligase -
PGW91_RS09130 (PGW91_09130) 1982540..1982794 + 255 WP_005892688.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PGW91_RS09135 (PGW91_09135) 1982787..1983047 + 261 WP_023037539.1 Txe/YoeB family addiction module toxin Toxin
PGW91_RS09140 (PGW91_09140) 1983057..1983561 + 505 Protein_1786 GNAT family N-acetyltransferase -
PGW91_RS09145 (PGW91_09145) 1983589..1984077 + 489 WP_271333823.1 GNAT family protein -
PGW91_RS09150 (PGW91_09150) 1984158..1984808 + 651 WP_032848409.1 endonuclease III -
PGW91_RS09155 (PGW91_09155) 1984887..1986083 + 1197 WP_005895386.1 cysteine desulfurase NifS -
PGW91_RS09160 (PGW91_09160) 1986146..1986532 + 387 WP_005895388.1 Fe-S cluster assembly scaffold protein NifU -
PGW91_RS09165 (PGW91_09165) 1986615..1987895 + 1281 WP_271333012.1 D-alanyl-D-alanine carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10296.80 Da        Isoelectric Point: 9.3654

>T268484 WP_023037539.1 NZ_CP116231:1982787-1983047 [Fusobacterium nucleatum]
MNNLVWTHKAWQDYLYWQTQDKKTLKKINELVKDIERNGALNGIGKPEVLKNESAYSRRIDEKNRLVYRIVDGFIWIIAC
KGHYEE

Download         Length: 261 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9824.17 Da        Isoelectric Point: 4.4453

>AT268484 WP_005892688.1 NZ_CP116231:1982540-1982794 [Fusobacterium nucleatum]
MLAINYTTLRTNLKSYFDKAVDNDEDIIITRKNERNVVLLSLDKYNEFLKAMRNLEYMTKIREGIAELEAGKGEIHDLIE
VDDE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U7TRZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A806UAF3

References