268483

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1820562..1821050 Replicon chromosome
Accession NZ_CP116231
Organism Fusobacterium nucleatum strain JD-Fn1

Toxin (Protein)


Gene name relE Uniprot ID X8HHY4
Locus tag PGW91_RS08405 Protein ID WP_032845982.1
Coordinates 1820562..1820825 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID X8HUL4
Locus tag PGW91_RS08410 Protein ID WP_023038160.1
Coordinates 1820826..1821050 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGW91_RS08370 (PGW91_08370) 1815779..1816339 - 561 WP_271332928.1 hypothetical protein -
PGW91_RS08375 (PGW91_08375) 1816353..1816757 - 405 WP_271332929.1 adhesion protein FadA -
PGW91_RS08380 (PGW91_08380) 1816910..1817413 - 504 WP_032845973.1 hypothetical protein -
PGW91_RS08385 (PGW91_08385) 1817602..1818069 + 468 WP_005901035.1 helix-turn-helix domain-containing protein -
PGW91_RS08390 (PGW91_08390) 1818020..1818445 + 426 WP_023038164.1 ImmA/IrrE family metallo-endopeptidase -
PGW91_RS08395 (PGW91_08395) 1818478..1819017 - 540 WP_271332930.1 TlpA disulfide reductase family protein -
PGW91_RS08400 (PGW91_08400) 1819039..1820496 - 1458 WP_271332931.1 HD domain-containing protein -
PGW91_RS08405 (PGW91_08405) 1820562..1820825 - 264 WP_032845982.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PGW91_RS08410 (PGW91_08410) 1820826..1821050 - 225 WP_023038160.1 DUF6290 family protein Antitoxin
PGW91_RS08415 (PGW91_08415) 1821120..1821881 - 762 Protein_1641 alanine:cation symporter family protein -
PGW91_RS08420 (PGW91_08420) 1821962..1823209 - 1248 WP_271332932.1 transposase -
PGW91_RS08425 (PGW91_08425) 1823803..1824438 - 636 Protein_1643 alanine:cation symporter family protein -
PGW91_RS08430 (PGW91_08430) 1824564..1826039 - 1476 WP_032847989.1 cobyric acid synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10618.50 Da        Isoelectric Point: 9.8829

>T268483 WP_032845982.1 NZ_CP116231:c1820825-1820562 [Fusobacterium nucleatum]
MYKVYFDKKVEKDFKKLDKKVLKLILDWIENNLENIEEPRSKGKALVGNLKDYWRYRIGDYRLITKIDDGKLLIITLELK
HRKEVYE

Download         Length: 264 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8713.05 Da        Isoelectric Point: 5.8834

>AT268483 WP_023038160.1 NZ_CP116231:c1821050-1820826 [Fusobacterium nucleatum]
MSNITLRLTDEEREILNNVAHLYGDKLSTAIKTILFEKIEEDYNLKIVKDFEKREKENKVELVSLSDFRKKLGV

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F0DVE4

Antitoxin

Source ID Structure
AlphaFold DB X8HUL4

References