Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 1603648..1604162 Replicon chromosome
Accession NZ_CP116231
Organism Fusobacterium nucleatum strain JD-Fn1

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag PGW91_RS07465 Protein ID WP_098978559.1
Coordinates 1603648..1603905 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID U7TQU0
Locus tag PGW91_RS07470 Protein ID WP_005919458.1
Coordinates 1603905..1604162 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGW91_RS07445 (PGW91_07445) 1599806..1600438 - 633 WP_271332831.1 hypothetical protein -
PGW91_RS07450 (PGW91_07450) 1600730..1601587 - 858 WP_271332832.1 toxin-antitoxin system YwqK family antitoxin -
PGW91_RS07455 (PGW91_07455) 1601709..1602446 - 738 WP_271332833.1 tRNA pseudouridine(38-40) synthase TruA -
PGW91_RS07460 (PGW91_07460) 1602455..1603531 - 1077 WP_271332834.1 DHH family phosphoesterase -
PGW91_RS07465 (PGW91_07465) 1603648..1603905 - 258 WP_098978559.1 Txe/YoeB family addiction module toxin Toxin
PGW91_RS07470 (PGW91_07470) 1603905..1604162 - 258 WP_005919458.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PGW91_RS07475 (PGW91_07475) 1604282..1604428 - 147 Protein_1468 glycerophosphodiester phosphodiesterase -
PGW91_RS07480 (PGW91_07480) 1604430..1605428 - 999 WP_271332835.1 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -
PGW91_RS07485 (PGW91_07485) 1605454..1605927 - 474 WP_005894577.1 OmpH family outer membrane protein -
PGW91_RS07490 (PGW91_07490) 1605967..1608060 - 2094 WP_271332836.1 outer membrane protein assembly factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10144.74 Da        Isoelectric Point: 9.7287

>T268482 WP_098978559.1 NZ_CP116231:c1603905-1603648 [Fusobacterium nucleatum]
MLLTWTDFAWKQYEELQEKDKRLIKKINILIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKVSDSQIIIVAC
ANHYK

Download         Length: 258 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10110.43 Da        Isoelectric Point: 4.7022

>AT268482 WP_005919458.1 NZ_CP116231:c1604162-1603905 [Fusobacterium nucleatum]
MIATNYSEVRNNLKAYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQKLVESIKEVEKGNVKEHD
LIEVD

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S2ZLE4

References