Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 301554..302083 Replicon plasmid unnamed1
Accession NZ_CP116225
Organism Actinomyces oris strain WVU627

Toxin (Protein)


Gene name parE Uniprot ID A0A1Q8WM14
Locus tag PGE45_RS12515 Protein ID WP_075379421.1
Coordinates 301554..301844 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1Q8WM28
Locus tag PGE45_RS12520 Protein ID WP_075379422.1
Coordinates 301841..302083 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGE45_RS12495 (PGE45_12495) 297084..298136 - 1053 WP_271289468.1 glycosyltransferase family 2 protein -
PGE45_RS12500 (PGE45_12500) 298133..299188 - 1056 WP_271289469.1 glycosyltransferase -
PGE45_RS12505 (PGE45_12505) 299332..300411 + 1080 WP_271289470.1 glycosyltransferase family 2 protein -
PGE45_RS12510 (PGE45_12510) 300484..301455 - 972 WP_271289471.1 diaminopimelate dehydrogenase -
PGE45_RS12515 (PGE45_12515) 301554..301844 - 291 WP_075379421.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PGE45_RS12520 (PGE45_12520) 301841..302083 - 243 WP_075379422.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
PGE45_RS12525 (PGE45_12525) 302227..305331 - 3105 WP_271289472.1 LamG domain-containing protein -
PGE45_RS12530 (PGE45_12530) 305785..306468 - 684 WP_256699478.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..415503 415503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11316.72 Da        Isoelectric Point: 8.9303

>T268481 WP_075379421.1 NZ_CP116225:c301844-301554 [Actinomyces oris]
VSTYRLTPAARRDLSRIWDYSEERWGLRQAEVYLRDLQTCLERLADDPRRGHPRDEVRPGYRSRAVGSHVVFYVISDGGV
DVIRVLHQRMDPDRHV

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8498.37 Da        Isoelectric Point: 4.3455

>AT268481 WP_075379422.1 NZ_CP116225:c302083-301841 [Actinomyces oris]
MSVNTSVSLDDHFVGFIASQVGSGRYRSASEVIRAGLRLLEDQETEMSALREALASGEASGQAEPFDFDAFIAAKAARTS

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q8WM14

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8WM28

References