Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1936932..1937545 Replicon chromosome
Accession NC_017522
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag CCDC5180_RS09055 Protein ID WP_003408465.1
Coordinates 1936932..1937321 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag CCDC5180_RS09060 Protein ID WP_003408469.1
Coordinates 1937318..1937545 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCDC5180_RS09025 1932559..1933473 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
CCDC5180_RS09030 1933476..1934306 + 831 WP_003408448.1 cyclase family protein -
CCDC5180_RS09035 1934306..1934656 + 351 WP_003898986.1 cupin domain-containing protein -
CCDC5180_RS09040 1934709..1935527 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
CCDC5180_RS09045 1935541..1936320 + 780 WP_003408460.1 IclR family transcriptional regulator -
CCDC5180_RS09055 1936932..1937321 - 390 WP_003408465.1 PIN domain-containing protein Toxin
CCDC5180_RS09060 1937318..1937545 - 228 WP_003408469.1 antitoxin Antitoxin
CCDC5180_RS09065 1937763..1939247 + 1485 WP_003408473.1 carboxylase -
CCDC5180_RS09070 1939244..1940491 + 1248 WP_003408476.1 serine hydrolase -
CCDC5180_RS09075 1940534..1940953 - 420 WP_003408483.1 hypothetical protein -
CCDC5180_RS09080 1940943..1941653 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T26848 WP_003408465.1 NC_017522:c1937321-1936932 [Mycobacterium tuberculosis CCDC5180]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T26848 NC_017522:c1937321-1936932 [Mycobacterium tuberculosis CCDC5180]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT26848 WP_003408469.1 NC_017522:c1937545-1937318 [Mycobacterium tuberculosis CCDC5180]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT26848 NC_017522:c1937545-1937318 [Mycobacterium tuberculosis CCDC5180]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
PDB 7E4J
AlphaFold DB A0A7U4FAN9

References