Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 451896..452467 Replicon chromosome
Accession NZ_CP116224
Organism Actinomyces oris strain WVU627

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PGE45_RS01920 Protein ID WP_271288857.1
Coordinates 451896..452273 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID F2UXK9
Locus tag PGE45_RS01925 Protein ID WP_003787711.1
Coordinates 452270..452467 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGE45_RS01905 (PGE45_01905) 448039..449280 + 1242 WP_271288854.1 hypothetical protein -
PGE45_RS01910 (PGE45_01910) 449617..451119 + 1503 WP_271288855.1 hypothetical protein -
PGE45_RS01915 (PGE45_01915) 451218..451814 - 597 WP_271288856.1 hypothetical protein -
PGE45_RS01920 (PGE45_01920) 451896..452273 - 378 WP_271288857.1 type II toxin-antitoxin system VapC family toxin Toxin
PGE45_RS01925 (PGE45_01925) 452270..452467 - 198 WP_003787711.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PGE45_RS01930 (PGE45_01930) 452723..455035 - 2313 WP_271288858.1 hypothetical protein -
PGE45_RS01935 (PGE45_01935) 455495..456823 + 1329 WP_271288859.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-42)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13801.86 Da        Isoelectric Point: 6.3263

>T268479 WP_271288857.1 NZ_CP116224:c452273-451896 [Actinomyces oris]
VILVDTSVWIDHFHHSDPVLVSLLHEDEIGSHPLVAEELAMGSLRSRDDVLKHLAHLRQFPVLSHDELLALVAAHALWGR
GLSPVDAHLLGSVMLVPGARLWTRDKRLLRAAEERGVSFTEGTAC

Download         Length: 378 bp

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6949.80 Da        Isoelectric Point: 11.5457

>AT268479 WP_003787711.1 NZ_CP116224:c452467-452270 [Actinomyces oris]
VRTTVTLSDDLIANAQELTGITERTELLRAGLETLVRVESARRLAALGGSDRTASAAPRRRSASQ

Download         Length: 198 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F1VW34

References