Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3935551..3937122 Replicon chromosome
Accession NZ_CP116223
Organism Proteus mirabilis strain PM1-chromosome

Toxin (Protein)


Gene name hipA Uniprot ID B4F0T8
Locus tag PG663_RS18125 Protein ID WP_012368637.1
Coordinates 3935551..3936864 (-) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B4F0T9
Locus tag PG663_RS18130 Protein ID WP_004249771.1
Coordinates 3936865..3937122 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG663_RS18105 (PG663_18105) 3930721..3931524 + 804 WP_060554978.1 energy transducer TonB -
PG663_RS18110 (PG663_18110) 3931578..3933539 - 1962 WP_172767808.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
PG663_RS18115 (PG663_18115) 3933571..3934500 - 930 WP_060554980.1 metallophosphoesterase -
PG663_RS18120 (PG663_18120) 3934685..3935149 - 465 WP_004246516.1 DUF1097 domain-containing protein -
PG663_RS18125 (PG663_18125) 3935551..3936864 - 1314 WP_012368637.1 type II toxin-antitoxin system HipA family toxin Toxin
PG663_RS18130 (PG663_18130) 3936865..3937122 - 258 WP_004249771.1 helix-turn-helix domain-containing protein Antitoxin
PG663_RS18135 (PG663_18135) 3937398..3938027 - 630 WP_001145449.1 hypothetical protein -
PG663_RS18140 (PG663_18140) 3938170..3938235 + 66 Protein_3517 EAL domain-containing protein -
PG663_RS18145 (PG663_18145) 3938375..3939139 - 765 WP_001389365.1 IS6-like element IS6100 family transposase -
PG663_RS18150 (PG663_18150) 3939257..3939325 - 69 Protein_3519 EAL domain-containing protein -
PG663_RS18155 (PG663_18155) 3939646..3940146 - 501 WP_000376623.1 GNAT family N-acetyltransferase -
PG663_RS18160 (PG663_18160) 3940274..3941113 - 840 WP_000259031.1 sulfonamide-resistant dihydropteroate synthase Sul1 -
PG663_RS18165 (PG663_18165) 3941107..3941454 - 348 WP_000679427.1 quaternary ammonium compound efflux SMR transporter QacE delta 1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49670.78 Da        Isoelectric Point: 6.5023

>T268478 WP_012368637.1 NZ_CP116223:c3936864-3935551 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT268478 WP_004249771.1 NZ_CP116223:c3937122-3936865 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4F0T8

Antitoxin

Source ID Structure
AlphaFold DB B4F0T9

References