Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3663325..3663974 Replicon chromosome
Accession NZ_CP116223
Organism Proteus mirabilis strain PM1-chromosome

Toxin (Protein)


Gene name vagD Uniprot ID B4EZB9
Locus tag PG663_RS16960 Protein ID WP_012368534.1
Coordinates 3663325..3663744 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B4EZC0
Locus tag PG663_RS16965 Protein ID WP_012368535.1
Coordinates 3663741..3663974 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG663_RS16930 (PG663_16930) 3658604..3659482 - 879 WP_004246812.1 23S rRNA pseudouridine(2604) synthase RluF -
PG663_RS16935 (PG663_16935) 3659658..3660572 - 915 WP_004249085.1 fatty acid biosynthesis protein FabY -
PG663_RS16940 (PG663_16940) 3660596..3661033 - 438 WP_004246810.1 D-aminoacyl-tRNA deacylase -
PG663_RS16945 (PG663_16945) 3661113..3661730 - 618 WP_020946398.1 glucose-1-phosphatase -
PG663_RS16950 (PG663_16950) 3662383..3662799 - 417 WP_046334846.1 hypothetical protein -
PG663_RS16955 (PG663_16955) 3662777..3663055 - 279 WP_230629709.1 hypothetical protein -
PG663_RS16960 (PG663_16960) 3663325..3663744 - 420 WP_012368534.1 type II toxin-antitoxin system VapC family toxin Toxin
PG663_RS16965 (PG663_16965) 3663741..3663974 - 234 WP_012368535.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PG663_RS16970 (PG663_16970) 3664724..3666559 - 1836 WP_004246802.1 ribosome-dependent GTPase TypA -
PG663_RS16975 (PG663_16975) 3666919..3668328 + 1410 WP_004246801.1 glutamate--ammonia ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(9-56)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15371.88 Da        Isoelectric Point: 7.7288

>T268477 WP_012368534.1 NZ_CP116223:c3663744-3663325 [Proteus mirabilis]
VKKVYMLDTNICSFIMREQPISLLEKLQKCVMNHDTIVISAITYSEMRFGAIGKKASPKHNRLVDAFCERVDAILAWDKA
AVDATTVIKKCLSDVGLPIGNNDSAIAGHAVAVNAILVTNNTREFSRVEGLKIEDWTHV

Download         Length: 420 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8890.06 Da        Isoelectric Point: 4.4870

>AT268477 WP_012368535.1 NZ_CP116223:c3663974-3663741 [Proteus mirabilis]
MRTRTVAVFKNGSNRAIRLPKDFDFDGVNELEISRDGDCIILRPVKPNWISLQNEEKADSDFLLERDDVIEEGRVIL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZB9

Antitoxin

Source ID Structure
AlphaFold DB B4EZC0

References