Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3642757..3643456 Replicon chromosome
Accession NZ_CP116223
Organism Proteus mirabilis strain PM1-chromosome

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag PG663_RS16855 Protein ID WP_004249093.1
Coordinates 3642757..3643143 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag PG663_RS16860 Protein ID WP_004246828.1
Coordinates 3643136..3643456 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG663_RS16840 (PG663_16840) 3638776..3639357 - 582 WP_004246833.1 DNA-3-methyladenine glycosylase I -
PG663_RS16845 (PG663_16845) 3639608..3640513 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
PG663_RS16850 (PG663_16850) 3640523..3642595 + 2073 WP_060554931.1 glycine--tRNA ligase subunit beta -
PG663_RS16855 (PG663_16855) 3642757..3643143 + 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PG663_RS16860 (PG663_16860) 3643136..3643456 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
PG663_RS16865 (PG663_16865) 3643505..3643939 - 435 WP_004246827.1 hypothetical protein -
PG663_RS16870 (PG663_16870) 3643932..3644816 - 885 WP_012368526.1 endonuclease/exonuclease/phosphatase family protein -
PG663_RS16875 (PG663_16875) 3645034..3646320 - 1287 WP_060554932.1 DUF3748 domain-containing protein -
PG663_RS16880 (PG663_16880) 3646457..3647074 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
PG663_RS16885 (PG663_16885) 3647376..3647999 + 624 WP_004246821.1 guanylate kinase -
PG663_RS16890 (PG663_16890) 3648054..3648329 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T268476 WP_004249093.1 NZ_CP116223:3642757-3643143 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT268476 WP_004246828.1 NZ_CP116223:3643136-3643456 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References