Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 3114401..3115422 | Replicon | chromosome |
| Accession | NZ_CP116223 | ||
| Organism | Proteus mirabilis strain PM1-chromosome | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | PG663_RS14455 | Protein ID | WP_004249488.1 |
| Coordinates | 3114853..3115422 (+) | Length | 190 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | - |
| Locus tag | PG663_RS14450 | Protein ID | WP_060554858.1 |
| Coordinates | 3114401..3114853 (+) | Length | 151 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PG663_RS14430 (PG663_14430) | 3110187..3110717 | - | 531 | WP_004245524.1 | RNA pyrophosphohydrolase | - |
| PG663_RS14435 (PG663_14435) | 3111034..3111999 | + | 966 | WP_020946190.1 | thiamine ABC transporter substrate binding subunit | - |
| PG663_RS14440 (PG663_14440) | 3111999..3113579 | + | 1581 | WP_046334723.1 | thiamine/thiamine pyrophosphate ABC transporter permease ThiP | - |
| PG663_RS14445 (PG663_14445) | 3113572..3114273 | + | 702 | WP_004245527.1 | thiamine ABC transporter ATP-binding protein ThiQ | - |
| PG663_RS14450 (PG663_14450) | 3114401..3114853 | + | 453 | WP_060554858.1 | helix-turn-helix domain-containing protein | Antitoxin |
| PG663_RS14455 (PG663_14455) | 3114853..3115422 | + | 570 | WP_004249488.1 | PIN domain-containing protein | Toxin |
| PG663_RS14460 (PG663_14460) | 3115538..3117892 | + | 2355 | WP_060554859.1 | DNA polymerase II | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 190 a.a. Molecular weight: 21600.10 Da Isoelectric Point: 7.3470
>T268475 WP_004249488.1 NZ_CP116223:3114853-3115422 [Proteus mirabilis]
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKNPP
MTVETFLGCLQKQKLPQFISHLRAFQILL
MTNYTVLLDACVMYPAPLRSYLMYLANTGLFRARWSNQIHDEWITNLLVNNPTLTAERLIRTRDLMNAHVPDCLVEGYEP
LICGLKLPDPNDRHVLAAAIKGQAQAIITFNLKDFPQKYLNSFDISAIHPDEFLSDMFELNPSSCIKAAQQHRQSLKNPP
MTVETFLGCLQKQKLPQFISHLRAFQILL
Download Length: 570 bp
Antitoxin
Download Length: 151 a.a. Molecular weight: 16730.18 Da Isoelectric Point: 5.7723
>AT268475 WP_060554858.1 NZ_CP116223:3114401-3114853 [Proteus mirabilis]
MNTISERLSTEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY
MNTISERLSTEDIALAKLSSQELSAVMDINGKTQKLSIIDKTGNNHIVQIPNSALRLMIEILTQLGQGNTVSITPIHAEL
TTQEAADILNMSRPTFVKLLDTRAIPYSRKGNRRKVAYADIVAYKNELEQKRLDALAELSQLDQEMDMGY
Download Length: 453 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|