268474

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rnlAB/RnlA-RnlB
Location 1502808..1504245 Replicon chromosome
Accession NZ_CP116223
Organism Proteus mirabilis strain PM1-chromosome

Toxin (Protein)


Gene name rnlA Uniprot ID -
Locus tag PG663_RS07070 Protein ID WP_060555088.1
Coordinates 1502808..1503881 (+) Length 358 a.a.

Antitoxin (Protein)


Gene name rnlB Uniprot ID -
Locus tag PG663_RS07075 Protein ID WP_060555086.1
Coordinates 1503874..1504245 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG663_RS07045 (PG663_07045) 1499354..1499932 + 579 WP_004247796.1 alpha/beta hydrolase -
PG663_RS07050 (PG663_07050) 1500045..1500671 - 627 WP_060555094.1 LysE family translocator -
PG663_RS07055 (PG663_07055) 1501437..1501772 + 336 WP_259693997.1 hypothetical protein -
PG663_RS07060 (PG663_07060) 1501759..1501893 + 135 Protein_1356 site-specific integrase -
PG663_RS07065 (PG663_07065) 1501974..1502357 + 384 WP_060555090.1 hypothetical protein -
PG663_RS07070 (PG663_07070) 1502808..1503881 + 1074 WP_060555088.1 type II toxin-antitoxin system RnlA family toxin Toxin
PG663_RS07075 (PG663_07075) 1503874..1504245 + 372 WP_060555086.1 type II toxin-antitoxin system RnlB family antitoxin Antitoxin
PG663_RS07080 (PG663_07080) 1504580..1505756 - 1177 Protein_1360 site-specific integrase -
PG663_RS07085 (PG663_07085) 1505758..1505955 - 198 WP_238985929.1 hypothetical protein -
PG663_RS07090 (PG663_07090) 1505945..1506142 - 198 WP_060555084.1 hypothetical protein -
PG663_RS07095 (PG663_07095) 1506348..1506464 + 117 Protein_1363 DUF1367 family protein -
PG663_RS07100 (PG663_07100) 1506476..1506742 + 267 WP_060555083.1 Ref family recombination enhancement nuclease -
PG663_RS07105 (PG663_07105) 1506772..1507305 + 534 Protein_1365 antiterminator Q family protein -
PG663_RS07110 (PG663_07110) 1507397..1508344 - 948 WP_060555081.1 hypothetical protein -
PG663_RS07115 (PG663_07115) 1508425..1508781 + 357 WP_238985928.1 phage holin, lambda family -
PG663_RS07120 (PG663_07120) 1508781..1509172 + 392 Protein_1368 M15 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterial toxin, RNase RnlA/LsoA, N-terminal

(6-88)

Antitoxin

Antitoxin RnlB/LsoB

(14-111)


Sequences

Toxin        


Download         Length: 358 a.a.        Molecular weight: 40621.81 Da        Isoelectric Point: 6.5823

>T268474 WP_060555088.1 NZ_CP116223:1502808-1503881 [Proteus mirabilis]
MTVRSYQDLNLDRANIETECRQFIQTRAYTVQSIGPMPGQRPGLRVTFAKIGENFATVNIFYNGNGSCTVQYLTGANRPL
GKELADYLFETINPAEFEHVNMVLEGFVENTILPVLELSAEETHIEFREHLRNHHSIMWKITSTTNQDELTVTLHTTTGK
LQIQGRPLSCYRVFIFNIAELLNLQGLEKVLIRQDDGKANIVQQEVARANLESIMGDAYPCLHAAAEKLLISGLCVKLAA
PKLPDYCMLLYPELRSIEGVLKNKMYAFGMSVQQPLGFGPFFDKVGLNYTLKLQYANTLRPEQVNIINDAYTFWNQERHA
VFHMETVVDTSRMISDMARLMTKATKAWQIIKDLYIV

Download         Length: 1074 bp

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13830.05 Da        Isoelectric Point: 4.3135

>AT268474 WP_060555086.1 NZ_CP116223:1503874-1504245 [Proteus mirabilis]
MFEITRVNVSGSLKAVVMATSYENPLSSVNEIEMKLTGLLGECENGKILFDLLCSNGPEWNRFVTLEIRLGRIMLDSAQI
IDQKEIPAQILSKLTFILQNHPEYLEASVLTPDDVRQVLSMDM

Download         Length: 372 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References