Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 4226077..4227806 Replicon chromosome
Accession NZ_CP116222
Organism Providencia vermicola strain PVA41-chromosome

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag PG365_RS19095 Protein ID WP_154623506.1
Coordinates 4226077..4226721 (+) Length 215 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag PG365_RS19100 Protein ID WP_154623505.1
Coordinates 4226733..4227806 (+) Length 358 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG365_RS19080 (PG365_19080) 4223663..4224493 + 831 WP_154624783.1 formate dehydrogenase accessory sulfurtransferase FdhD -
PG365_RS19085 (PG365_19085) 4224497..4225276 - 780 WP_154624784.1 transferase -
PG365_RS19090 (PG365_19090) 4225508..4226077 + 570 WP_154623507.1 DarT ssDNA thymidine ADP-ribosyltransferase family protein -
PG365_RS19095 (PG365_19095) 4226077..4226721 + 645 WP_154623506.1 DUF4433 domain-containing protein Toxin
PG365_RS19100 (PG365_19100) 4226733..4227806 + 1074 WP_154623505.1 macro domain-containing protein Antitoxin
PG365_RS19105 (PG365_19105) 4228035..4228664 - 630 WP_001145449.1 hypothetical protein -
PG365_RS19110 (PG365_19110) 4228807..4228872 + 66 Protein_3697 EAL domain-containing protein -
PG365_RS19115 (PG365_19115) 4229012..4229776 - 765 WP_001389365.1 IS6-like element IS6100 family transposase -
PG365_RS19125 (PG365_19125) 4230283..4230783 - 501 WP_000376623.1 GNAT family N-acetyltransferase -
PG365_RS19130 (PG365_19130) 4230911..4231750 - 840 WP_000259031.1 sulfonamide-resistant dihydropteroate synthase Sul1 -
PG365_RS19135 (PG365_19135) 4231744..4232091 - 348 WP_112040837.1 quaternary ammonium compound efflux SMR transporter QacE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(14-214)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 215 a.a.        Molecular weight: 25047.66 Da        Isoelectric Point: 6.9106

>T268471 WP_154623506.1 NZ_CP116222:4226077-4226721 [Providencia vermicola]
MAYMNLNPEKALIWRITHRQNIPWLFANGLYAGNSEHYSPNWVTIGNTDLINRRNQRHVPIQPNGVLNDYVPFYFTPFSP
MMYNIYTGRGGVRKVPNDDIIILVSSMYKIAALKIPFVFTDRHAYPVTSQFYNQLTDLAEIDWALLQQRNFHRDPDDPEK
VERYQAEALIYKHVPMEALLGAVCYTKETQLELQAKASQLEIHLDIHCIPNWYF

Download         Length: 645 bp

Antitoxin


Download         Length: 358 a.a.        Molecular weight: 40807.28 Da        Isoelectric Point: 7.8198

>AT268471 WP_154623505.1 NZ_CP116222:4226733-4227806 [Providencia vermicola]
MIEFTQGNLLEADVEALVNTVNTVGVMGKGIALMFKERFPANMAAYAKACKTHEVQTGKMFVTETGELMGPRWIVNFPTK
QHWRAKSQIQWIIDGLLDLRNFIEENHVKSIAIPPLGAGNGGLNWDDVKPHIVEILGDIQNVKIIVYEPIAKYQNVAKPK
GVEKLTPARALIAELIRRYWVMGMDCSLLEIQKLAWFLERTIEAEGLRNPLNLRFEARNYGPYADKLRHLLNGLDGSYLK
SEKRISDCSPLDVIWFNDDKRATIELYLKTEAKDYLSALEKTTKLIDGFESPFGIELLSTVDWLLYKKQSSPNIESLLEG
MRQWPAGDRWAQRKLRLFDSNKLELALNHLKQIPFYS

Download         Length: 1074 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References