Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 877546..878196 Replicon chromosome
Accession NZ_CP116222
Organism Providencia vermicola strain PVA41-chromosome

Toxin (Protein)


Gene name Hha Uniprot ID K8W3H1
Locus tag PG365_RS03750 Protein ID WP_004927064.1
Coordinates 877546..877749 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag PG365_RS03755 Protein ID WP_154635730.1
Coordinates 877828..878196 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PG365_RS03725 (PG365_03725) 873426..873764 + 339 WP_154622397.1 P-II family nitrogen regulator -
PG365_RS03730 (PG365_03730) 873775..875058 + 1284 WP_251465118.1 ammonium transporter AmtB -
PG365_RS03735 (PG365_03735) 875286..876152 - 867 WP_251465121.1 acyl-CoA thioesterase II -
PG365_RS03740 (PG365_03740) 876477..876935 + 459 WP_251465123.1 YbaY family lipoprotein -
PG365_RS03750 (PG365_03750) 877546..877749 - 204 WP_004927064.1 HHA domain-containing protein Toxin
PG365_RS03755 (PG365_03755) 877828..878196 - 369 WP_154635730.1 Hha toxicity modulator TomB Antitoxin
PG365_RS03760 (PG365_03760) 878764..880101 - 1338 WP_154624041.1 murein transglycosylase D -
PG365_RS03765 (PG365_03765) 880180..880935 - 756 WP_154624042.1 hydroxyacylglutathione hydrolase -
PG365_RS03770 (PG365_03770) 880975..881700 + 726 WP_154624043.1 methyltransferase domain-containing protein -
PG365_RS03775 (PG365_03775) 881767..882237 - 471 WP_154624044.1 ribonuclease HI -
PG365_RS03780 (PG365_03780) 882292..883053 + 762 WP_154624045.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8075.37 Da        Isoelectric Point: 6.9770

>T268468 WP_004927064.1 NZ_CP116222:c877749-877546 [Providencia vermicola]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14106.92 Da        Isoelectric Point: 4.3486

>AT268468 WP_154635730.1 NZ_CP116222:c878196-877828 [Providencia vermicola]
MDEYSPKNYDISELKYLCNSLNREAISSLQKTNTHWINDLSSPQSVRLNELIEHIAAFVWQYKIKHPKDNLVISLVEEYL
DETYDLFGSPVITLSEIIDWQSMNQNLVAVLDDDLKCPASKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K8W3H1

Antitoxin

Source ID Structure

References