Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 176420..176955 Replicon plasmid p2562_2
Accession NZ_CP116216
Organism Klebsiella michiganensis strain 2563

Toxin (Protein)


Gene name relE Uniprot ID A0A6M4NRI2
Locus tag PHA56_RS30965 Protein ID WP_032693963.1
Coordinates 176668..176955 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8G2A2B7
Locus tag PHA56_RS30960 Protein ID WP_032752108.1
Coordinates 176420..176671 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA56_RS30930 (PHA56_30930) 171789..172068 - 280 Protein_185 hypothetical protein -
PHA56_RS30935 (PHA56_30935) 172386..172616 - 231 WP_047665741.1 hypothetical protein -
PHA56_RS30940 (PHA56_30940) 172680..173351 - 672 WP_032700854.1 plasmid partitioning/stability family protein -
PHA56_RS30945 (PHA56_30945) 173354..174325 - 972 WP_077255421.1 plasmid segregation protein ParM -
PHA56_RS30950 (PHA56_30950) 174544..174987 + 444 WP_040118420.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
PHA56_RS30955 (PHA56_30955) 174987..176255 + 1269 WP_032752101.1 Y-family DNA polymerase -
PHA56_RS30960 (PHA56_30960) 176420..176671 + 252 WP_032752108.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PHA56_RS30965 (PHA56_30965) 176668..176955 + 288 WP_032693963.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PHA56_RS30970 (PHA56_30970) 177555..178756 + 1202 WP_096913407.1 IS3 family transposase -
PHA56_RS30975 (PHA56_30975) 179383..179655 + 273 Protein_194 DNA polymerase V subunit UmuC -
PHA56_RS30980 (PHA56_30980) 180321..181292 - 972 WP_032752114.1 ParB/RepB/Spo0J family plasmid partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..183276 183276


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11133.12 Da        Isoelectric Point: 10.2246

>T268465 WP_032693963.1 NZ_CP116216:176668-176955 [Klebsiella michiganensis]
MTYTVKFREDALKEWQKLDKAIQQQFAKKLKKCCDEPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDDQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9174.43 Da        Isoelectric Point: 3.9507

>AT268465 WP_032752108.1 NZ_CP116216:176420-176671 [Klebsiella michiganensis]
MPNIILSDTSASISELKKNPMATVSAGDGFPVAILNRNQPAFYCIPAELYEKMLDALDDQELAKLVSERSNQQLLDVDLD
TYL

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6M4NRI2

Antitoxin

Source ID Structure

References