Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 63567..64093 Replicon plasmid p2562_1
Accession NZ_CP116215
Organism Klebsiella michiganensis strain 2563

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag PHA56_RS28445 Protein ID WP_000323025.1
Coordinates 63806..64093 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag PHA56_RS28440 Protein ID WP_004196370.1
Coordinates 63567..63806 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA56_RS28405 (PHA56_28405) 58904..59096 - 193 Protein_59 MFS transporter -
PHA56_RS28410 (PHA56_28410) 59126..60103 + 978 WP_004196334.1 chromate resistance protein -
PHA56_RS28415 (PHA56_28415) 60060..61436 + 1377 WP_004196363.1 chromate efflux transporter -
PHA56_RS28420 (PHA56_28420) 61467..62156 - 690 WP_004196322.1 hypothetical protein -
PHA56_RS28425 (PHA56_28425) 62170..62907 - 738 WP_008460272.1 HupE/UreJ family protein -
PHA56_RS28430 (PHA56_28430) 62951..63316 - 366 WP_009651956.1 hypothetical protein -
PHA56_RS28435 (PHA56_28435) 63444..63542 - 99 Protein_65 protein YdfV -
PHA56_RS28440 (PHA56_28440) 63567..63806 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
PHA56_RS28445 (PHA56_28445) 63806..64093 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
PHA56_RS28450 (PHA56_28450) 64165..64323 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
PHA56_RS28455 (PHA56_28455) 64929..65903 + 975 WP_004196336.1 hypothetical protein -
PHA56_RS28460 (PHA56_28460) 65887..66009 + 123 WP_254911979.1 hypothetical protein -
PHA56_RS28465 (PHA56_28465) 66101..66478 - 378 WP_045289277.1 hypothetical protein -
PHA56_RS28470 (PHA56_28470) 66805..67101 + 297 WP_094313394.1 hydrogenase expression/formation protein HypD -
PHA56_RS28475 (PHA56_28475) 67170..68237 + 1068 WP_049130554.1 hypothetical protein -
PHA56_RS28480 (PHA56_28480) 68393..68740 + 348 WP_042935949.1 hypothetical protein -
PHA56_RS28485 (PHA56_28485) 68819..69052 + 234 WP_042935952.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid formA - 1..362448 362448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T268461 WP_000323025.1 NZ_CP116215:63806-64093 [Klebsiella michiganensis]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT268461 WP_004196370.1 NZ_CP116215:63567-63806 [Klebsiella michiganensis]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References