Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 5245831..5246407 Replicon chromosome
Accession NZ_CP116214
Organism Klebsiella michiganensis strain 2563

Toxin (Protein)


Gene name shpA Uniprot ID A0A1D8JNH2
Locus tag PHA56_RS24795 Protein ID WP_042933975.1
Coordinates 5246120..5246407 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag PHA56_RS24790 Protein ID WP_014837314.1
Coordinates 5245831..5246133 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA56_RS24775 (PHA56_24775) 5242668..5243003 + 336 WP_032719937.1 endoribonuclease SymE -
PHA56_RS24780 (PHA56_24780) 5243458..5244369 + 912 WP_119834584.1 acetamidase/formamidase family protein -
PHA56_RS24785 (PHA56_24785) 5244366..5245709 + 1344 WP_119834583.1 APC family permease -
PHA56_RS24790 (PHA56_24790) 5245831..5246133 - 303 WP_014837314.1 BrnA antitoxin family protein Antitoxin
PHA56_RS24795 (PHA56_24795) 5246120..5246407 - 288 WP_042933975.1 BrnT family toxin Toxin
PHA56_RS24800 (PHA56_24800) 5246657..5247100 - 444 WP_014837312.1 FosA family fosfomycin resistance glutathione transferase -
PHA56_RS24805 (PHA56_24805) 5247094..5248002 - 909 WP_119834582.1 LysR family transcriptional regulator -
PHA56_RS24810 (PHA56_24810) 5248090..5248872 + 783 WP_032693033.1 NAD(P)H-dependent oxidoreductase -
PHA56_RS24815 (PHA56_24815) 5249020..5249604 + 585 WP_004098242.1 TetR/AcrR family transcriptional regulator -
PHA56_RS24820 (PHA56_24820) 5249750..5250550 + 801 WP_014227752.1 winged helix-turn-helix domain-containing protein -
PHA56_RS24825 (PHA56_24825) 5250547..5251065 + 519 WP_042944214.1 FidL-like protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(39-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11239.69 Da        Isoelectric Point: 8.5899

>T268460 WP_042933975.1 NZ_CP116214:c5246407-5246120 [Klebsiella michiganensis]
MPMEFEWDANKARSNLRKHGIRFEEAVLVFDDPRHLSRQDRYENGEYRWQTIGLVHGVIVIMVAHSVRFESGTEVIRIIS
ARKADSKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11549.14 Da        Isoelectric Point: 9.7962

>AT268460 WP_014837314.1 NZ_CP116214:c5246133-5245831 [Klebsiella michiganensis]
MNMVKHKRDNPDTLTAKRDDELKALANKTDDEIDYSGIPATDDAQWSDAVRGKFYRPLKTQASVRIDADIMEWLKRPGKG
YQTRLNAILREAMIRDLNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D8JNH2

Antitoxin

Source ID Structure

References