Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1685387..1686003 Replicon chromosome
Accession NC_017522
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag CCDC5180_RS07980 Protein ID WP_003407593.1
Coordinates 1685686..1686003 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag CCDC5180_RS07975 Protein ID WP_003900349.1
Coordinates 1685387..1685689 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCDC5180_RS07965 1681273..1683120 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
CCDC5180_RS07970 1683121..1685373 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
CCDC5180_RS07975 1685387..1685689 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
CCDC5180_RS07980 1685686..1686003 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
CCDC5180_RS07985 1686000..1687004 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
CCDC5180_RS07990 1687057..1688346 + 1290 WP_003902090.1 serine hydrolase -
CCDC5180_RS07995 1688419..1689192 - 774 WP_003912632.1 class I SAM-dependent methyltransferase -
CCDC5180_RS08000 1689250..1689462 - 213 WP_003898900.1 dodecin family protein -
CCDC5180_RS22595 1689472..1689696 - 225 WP_160522526.1 NUDIX domain-containing protein -
CCDC5180_RS08010 1689966..1690994 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T26846 WP_003407593.1 NC_017522:1685686-1686003 [Mycobacterium tuberculosis CCDC5180]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T26846 NC_017522:1685686-1686003 [Mycobacterium tuberculosis CCDC5180]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT26846 WP_003900349.1 NC_017522:1685387-1685689 [Mycobacterium tuberculosis CCDC5180]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT26846 NC_017522:1685387-1685689 [Mycobacterium tuberculosis CCDC5180]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
PDB 5XE3
AlphaFold DB G0TJ73

References