Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 4753655..4754474 Replicon chromosome
Accession NZ_CP116214
Organism Klebsiella michiganensis strain 2563

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag PHA56_RS22475 Protein ID WP_004110819.1
Coordinates 4754217..4754474 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag PHA56_RS22470 Protein ID WP_047684097.1
Coordinates 4753655..4754206 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA56_RS22440 (PHA56_22440) 4749579..4750352 + 774 WP_103433587.1 Zygote formation protein zyg1 -
PHA56_RS22445 (PHA56_22445) 4750663..4751136 + 474 WP_032693194.1 hypothetical protein -
PHA56_RS22450 (PHA56_22450) 4751405..4751754 - 350 Protein_4417 type II toxin-antitoxin system VapC family toxin -
PHA56_RS22455 (PHA56_22455) 4751817..4751975 - 159 Protein_4418 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
PHA56_RS22460 (PHA56_22460) 4752009..4752755 - 747 WP_223226754.1 class I SAM-dependent methyltransferase -
PHA56_RS22465 (PHA56_22465) 4753179..4753541 - 363 Protein_4420 class I SAM-dependent methyltransferase -
PHA56_RS22470 (PHA56_22470) 4753655..4754206 - 552 WP_047684097.1 N-acetyltransferase Antitoxin
PHA56_RS22475 (PHA56_22475) 4754217..4754474 - 258 WP_004110819.1 YjhX family toxin Toxin
PHA56_RS22480 (PHA56_22480) 4755150..4756334 + 1185 WP_014228054.1 mannonate dehydratase -
PHA56_RS22485 (PHA56_22485) 4756408..4757883 + 1476 WP_119834689.1 fructuronate reductase -
PHA56_RS22490 (PHA56_22490) 4758022..4758798 + 777 WP_004847986.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(22-130)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T268459 WP_004110819.1 NZ_CP116214:c4754474-4754217 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 19842.60 Da        Isoelectric Point: 6.4897

>AT268459 WP_047684097.1 NZ_CP116214:c4754206-4753655 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGELIRHGIEQLKAMGSQAVFVLGHAACYPRHGFEPGAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure

References