268458

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4525324..4525943 Replicon chromosome
Accession NZ_CP116214
Organism Klebsiella michiganensis strain 2563

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag PHA56_RS21375 Protein ID WP_004099646.1
Coordinates 4525725..4525943 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H3N7X7
Locus tag PHA56_RS21370 Protein ID WP_004129911.1
Coordinates 4525324..4525698 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA56_RS21360 (PHA56_21360) 4520481..4521674 + 1194 WP_004136054.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PHA56_RS21365 (PHA56_21365) 4521697..4524843 + 3147 WP_221686856.1 multidrug efflux RND transporter permease subunit AcrB -
PHA56_RS21370 (PHA56_21370) 4525324..4525698 + 375 WP_004129911.1 Hha toxicity modulator TomB Antitoxin
PHA56_RS21375 (PHA56_21375) 4525725..4525943 + 219 WP_004099646.1 HHA domain-containing protein Toxin
PHA56_RS21380 (PHA56_21380) 4526106..4526672 + 567 WP_038424164.1 maltose O-acetyltransferase -
PHA56_RS21385 (PHA56_21385) 4526644..4526778 - 135 WP_223226764.1 hypothetical protein -
PHA56_RS21390 (PHA56_21390) 4526799..4527269 + 471 WP_014228205.1 YlaC family protein -
PHA56_RS21395 (PHA56_21395) 4527244..4528698 - 1455 WP_038424163.1 PLP-dependent aminotransferase family protein -
PHA56_RS21400 (PHA56_21400) 4528800..4529498 + 699 WP_014228203.1 GNAT family protein -
PHA56_RS21405 (PHA56_21405) 4529495..4529635 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
PHA56_RS21410 (PHA56_21410) 4529635..4529898 - 264 WP_004848323.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T268458 WP_004099646.1 NZ_CP116214:4525725-4525943 [Klebsiella michiganensis]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT268458 WP_004129911.1 NZ_CP116214:4525324-4525698 [Klebsiella michiganensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3HD25

References