Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1327495..1328278 Replicon chromosome
Accession NZ_CP116214
Organism Klebsiella michiganensis strain 2563

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag PHA56_RS06390 Protein ID WP_039077579.1
Coordinates 1327495..1327869 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag PHA56_RS06395 Protein ID WP_039077578.1
Coordinates 1327919..1328278 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA56_RS06365 (PHA56_06365) 1322949..1323857 + 909 WP_032938037.1 kdo(2)-lipid IV(A) palmitoleoyltransferase -
PHA56_RS06370 (PHA56_06370) 1324631..1325104 + 474 WP_228291928.1 glycosyltransferase family 2 protein -
PHA56_RS06375 (PHA56_06375) 1325180..1326408 + 1229 WP_104159316.1 IS3 family transposase -
PHA56_RS06380 (PHA56_06380) 1326393..1326956 + 564 WP_228291929.1 hypothetical protein -
PHA56_RS06385 (PHA56_06385) 1326960..1327418 + 459 WP_224232182.1 hypothetical protein -
PHA56_RS06390 (PHA56_06390) 1327495..1327869 - 375 WP_039077579.1 TA system toxin CbtA family protein Toxin
PHA56_RS06395 (PHA56_06395) 1327919..1328278 - 360 WP_039077578.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PHA56_RS06400 (PHA56_06400) 1328301..1328522 - 222 WP_032938028.1 DUF987 domain-containing protein -
PHA56_RS06405 (PHA56_06405) 1328536..1329018 - 483 WP_039077577.1 DNA repair protein RadC -
PHA56_RS06410 (PHA56_06410) 1329259..1329738 - 480 WP_082027055.1 antirestriction protein -
PHA56_RS06415 (PHA56_06415) 1329818..1330639 - 822 WP_039077576.1 DUF932 domain-containing protein -
PHA56_RS06420 (PHA56_06420) 1330750..1330962 - 213 WP_032938024.1 hypothetical protein -
PHA56_RS06425 (PHA56_06425) 1331072..1331545 - 474 WP_032938022.1 hypothetical protein -
PHA56_RS06430 (PHA56_06430) 1331619..1332248 - 630 WP_039077575.1 hypothetical protein -
PHA56_RS06435 (PHA56_06435) 1332346..1333023 - 678 WP_039077574.1 WYL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1297582..1349493 51911


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(9-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13875.91 Da        Isoelectric Point: 10.3681

>T268452 WP_039077579.1 NZ_CP116214:c1327869-1327495 [Klebsiella michiganensis]
MQKQSLSPHRAASSRLSSVEIWRKLLKYLLEQHYGLTLNDTPFGNDSVIQKHIDAGISLCYAVNFIVEKYDLVRTDRHGF
SVKEQSPFIGSIDMLRARKATGLMTRKGYKTVTDISGGRSSGGK

Download         Length: 375 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13317.39 Da        Isoelectric Point: 7.4144

>AT268452 WP_039077578.1 NZ_CP116214:c1328278-1327919 [Klebsiella michiganensis]
MQKATRVINHNIAEPWWGLRRNITPCFGARLVHEGNHLHYLADRASIAGTFNDADLRHLDQAFPVLMKQMELMLTSSELT
PHIQRCITLHAKGLICEADTLGSCGYLYIVIYPASATTA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References