Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 846427..847084 Replicon chromosome
Accession NZ_CP116214
Organism Klebsiella michiganensis strain 2563

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag PHA56_RS04095 Protein ID WP_004854060.1
Coordinates 846674..847084 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag PHA56_RS04090 Protein ID WP_004124953.1
Coordinates 846427..846693 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA56_RS04075 (PHA56_04075) 841661..842086 - 426 WP_032720093.1 PTS sugar transporter subunit IIA -
PHA56_RS04080 (PHA56_04080) 842207..845005 - 2799 WP_014226794.1 transcriptional regulator DagR -
PHA56_RS04085 (PHA56_04085) 845199..846182 - 984 WP_032720095.1 tRNA-modifying protein YgfZ -
PHA56_RS04090 (PHA56_04090) 846427..846693 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
PHA56_RS04095 (PHA56_04095) 846674..847084 + 411 WP_004854060.1 protein YgfX Toxin
PHA56_RS04100 (PHA56_04100) 847093..847614 - 522 WP_014226792.1 flavodoxin FldB -
PHA56_RS04105 (PHA56_04105) 847736..848632 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
PHA56_RS04110 (PHA56_04110) 848655..849368 + 714 WP_004854054.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PHA56_RS04115 (PHA56_04115) 849374..851107 + 1734 WP_038423602.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T268451 WP_004854060.1 NZ_CP116214:846674-847084 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT268451 WP_004124953.1 NZ_CP116214:846427-846693 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References