Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 691036..691739 Replicon chromosome
Accession NZ_CP116214
Organism Klebsiella michiganensis strain 2563

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag PHA56_RS03330 Protein ID WP_119834388.1
Coordinates 691398..691739 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag PHA56_RS03325 Protein ID WP_119834410.1
Coordinates 691036..691377 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA56_RS03285 (PHA56_03285) 686588..687292 + 705 WP_119834393.1 WYL domain-containing protein -
PHA56_RS03290 (PHA56_03290) 687292..687861 + 570 WP_119834392.1 hypothetical protein -
PHA56_RS03295 (PHA56_03295) 687876..688328 + 453 WP_100168667.1 hypothetical protein -
PHA56_RS03300 (PHA56_03300) 688325..688774 + 450 WP_071199563.1 IrmA family protein -
PHA56_RS03305 (PHA56_03305) 688846..689076 + 231 WP_119834391.1 DUF905 domain-containing protein -
PHA56_RS03310 (PHA56_03310) 689175..689996 + 822 WP_119834390.1 DUF932 domain-containing protein -
PHA56_RS03315 (PHA56_03315) 690027..690470 + 444 WP_025205062.1 antirestriction protein -
PHA56_RS03320 (PHA56_03320) 690483..691025 + 543 WP_119834389.1 DNA repair protein RadC -
PHA56_RS03325 (PHA56_03325) 691036..691377 + 342 WP_119834410.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PHA56_RS03330 (PHA56_03330) 691398..691739 + 342 WP_119834388.1 TA system toxin CbtA family protein Toxin
PHA56_RS03340 (PHA56_03340) 692101..692607 + 507 WP_009651862.1 G/U mismatch-specific DNA glycosylase -
PHA56_RS03345 (PHA56_03345) 692677..693339 - 663 WP_032692890.1 TetR/AcrR family transcriptional regulator -
PHA56_RS03350 (PHA56_03350) 693580..695424 - 1845 WP_004105908.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12850.81 Da        Isoelectric Point: 9.6542

>T268450 WP_119834388.1 NZ_CP116214:691398-691739 [Klebsiella michiganensis]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVDKYELVRIDRRGF
NWQEQSPYLRAVDILRARQATGLLRRSRNNAVS

Download         Length: 342 bp

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12932.51 Da        Isoelectric Point: 5.9608

>AT268450 WP_119834410.1 NZ_CP116214:691036-691377 [Klebsiella michiganensis]
MKSTDSENDSFLKWGLNRNETPCFGARLVQEGNRLHYLANRASITGEFINTEYLKLDEIFPHFISQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYISVYPTQR

Download         Length: 342 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References