Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 57237..57784 Replicon chromosome
Accession NZ_CP116214
Organism Klebsiella michiganensis strain 2563

Toxin (Protein)


Gene name ccdB Uniprot ID A0A0H3H5T3
Locus tag PHA56_RS00290 Protein ID WP_014227299.1
Coordinates 57237..57545 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0H3H0P7
Locus tag PHA56_RS00295 Protein ID WP_014227298.1
Coordinates 57548..57784 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA56_RS00260 (PHA56_00260) 52884..53195 - 312 WP_271292944.1 PTS sugar transporter subunit IIB -
PHA56_RS00265 (PHA56_00265) 53490..54431 + 942 WP_014227303.1 LacI family DNA-binding transcriptional regulator -
PHA56_RS00270 (PHA56_00270) 54455..54748 - 294 WP_014227302.1 YicS family protein -
PHA56_RS00275 (PHA56_00275) 54958..55923 + 966 WP_038423881.1 Rpn family recombination-promoting nuclease/putative transposase -
PHA56_RS00280 (PHA56_00280) 55923..56180 + 258 WP_032718834.1 hypothetical protein -
PHA56_RS00285 (PHA56_00285) 56184..57086 - 903 WP_009654083.1 DMT family transporter -
PHA56_RS00290 (PHA56_00290) 57237..57545 - 309 WP_014227299.1 CcdB family protein Toxin
PHA56_RS00295 (PHA56_00295) 57548..57784 - 237 WP_014227298.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PHA56_RS00300 (PHA56_00300) 57890..59323 - 1434 WP_038423880.1 PTS N-acetylmuramic acid transporter subunit IIBC -
PHA56_RS00305 (PHA56_00305) 59348..60250 - 903 WP_038423879.1 N-acetylmuramic acid 6-phosphate etherase -
PHA56_RS00310 (PHA56_00310) 60411..61577 - 1167 WP_014839828.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11725.57 Da        Isoelectric Point: 7.2729

>T268449 WP_014227299.1 NZ_CP116214:c57545-57237 [Klebsiella michiganensis]
MQYYVYKNTGRIAAYPYLLDVQSDIIGKRNTRVVIPLFPLKNYKGPRADRLTPLVTVEGEEYVVMTHELASIPHRVLGEE
VCNLNHQREVVKASMDFLFDGI

Download         Length: 309 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8783.92 Da        Isoelectric Point: 5.7928

>AT268449 WP_014227298.1 NZ_CP116214:c57784-57548 [Klebsiella michiganensis]
MPAAKRNKQNVSVTLDPGLVKQAREVGINLSLTLTNALKSEIHSLEIARWQKENAQAIDYLNNLTEENGLLSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H5T3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H0P7

References