Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2475356..2476331 Replicon chromosome
Accession NZ_CP116204
Organism Bacillus paranthracis strain NVH_0075/95

Toxin (Protein)


Gene name spoIISA Uniprot ID B7HS47
Locus tag PGS39_RS12815 Protein ID WP_002027714.1
Coordinates 2475356..2476093 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag PGS39_RS12820 Protein ID WP_000588712.1
Coordinates 2476206..2476331 (+) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGS39_RS12785 (PGS39_12785) 2470431..2471141 + 711 WP_000787481.1 class I SAM-dependent methyltransferase -
PGS39_RS12790 (PGS39_12790) 2471261..2471668 + 408 WP_000072484.1 VOC family protein -
PGS39_RS12795 (PGS39_12795) 2471774..2471866 + 93 Protein_2440 methyltransferase -
PGS39_RS12800 (PGS39_12800) 2471988..2473673 - 1686 WP_002027713.1 alpha-keto acid decarboxylase family protein -
PGS39_RS12805 (PGS39_12805) 2473780..2474262 + 483 WP_000191904.1 MarR family transcriptional regulator -
PGS39_RS12810 (PGS39_12810) 2474430..2475167 + 738 WP_000594123.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
PGS39_RS12815 (PGS39_12815) 2475356..2476093 + 738 WP_002027714.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PGS39_RS12820 (PGS39_12820) 2476206..2476331 + 126 WP_000588712.1 hypothetical protein Antitoxin
PGS39_RS12825 (PGS39_12825) 2476407..2476583 + 177 WP_000852618.1 stage II sporulation protein SB -
PGS39_RS12830 (PGS39_12830) 2476727..2478196 + 1470 WP_000287521.1 beta-Ala-His dipeptidase -
PGS39_RS12835 (PGS39_12835) 2478273..2478644 - 372 WP_000670600.1 DUF5065 family protein -
PGS39_RS12840 (PGS39_12840) 2478787..2479380 + 594 WP_000265892.1 SGNH/GDSL hydrolase family protein -
PGS39_RS12845 (PGS39_12845) 2479602..2480135 + 534 WP_000438318.1 sigma-70 family RNA polymerase sigma factor -
PGS39_RS12850 (PGS39_12850) 2480125..2480952 + 828 WP_001060779.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28415.15 Da        Isoelectric Point: 8.2672

>T268447 WP_002027714.1 NZ_CP116204:2475356-2476093 [Bacillus paranthracis]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTSIIQNVNPVVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT268447 WP_000588712.1 NZ_CP116204:2476206-2476331 [Bacillus paranthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M9H7T3

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References