268446

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 249440..250082 Replicon chromosome
Accession NZ_CP116204
Organism Bacillus paranthracis strain NVH_0075/95

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag PGS39_RS01395 Protein ID WP_000635963.1
Coordinates 249732..250082 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag PGS39_RS01390 Protein ID WP_000004570.1
Coordinates 249440..249727 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PGS39_RS01365 (PGS39_01365) 244764..245726 + 963 WP_000961151.1 UV DNA damage repair endonuclease UvsE -
PGS39_RS01370 (PGS39_01370) 245719..246291 - 573 WP_000906919.1 rhomboid family intramembrane serine protease -
PGS39_RS01375 (PGS39_01375) 246384..246743 + 360 WP_000635037.1 holo-ACP synthase -
PGS39_RS01380 (PGS39_01380) 246900..247850 + 951 WP_025991724.1 outer membrane lipoprotein carrier protein LolA -
PGS39_RS01385 (PGS39_01385) 247969..249138 + 1170 WP_000390601.1 alanine racemase -
PGS39_RS01390 (PGS39_01390) 249440..249727 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
PGS39_RS01395 (PGS39_01395) 249732..250082 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
PGS39_RS01400 (PGS39_01400) 250150..252318 + 2169 WP_000450602.1 Tex family protein -
PGS39_RS01405 (PGS39_01405) 252376..252492 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
PGS39_RS01410 (PGS39_01410) 252688..253146 + 459 WP_000344246.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T268446 WP_000635963.1 NZ_CP116204:249732-250082 [Bacillus paranthracis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT268446 WP_000004570.1 NZ_CP116204:249440-249727 [Bacillus paranthracis]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References