Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 21365..22008 Replicon plasmid pDETEC88
Accession NZ_CP116199
Organism Escherichia coli strain DETEC-C31

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag PIB97_RS24080 Protein ID WP_001044768.1
Coordinates 21592..22008 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag PIB97_RS24075 Protein ID WP_001261287.1
Coordinates 21365..21595 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB97_RS24055 (16525) 16525..17613 + 1089 WP_000952217.1 transcriptional repressor PifC -
PIB97_RS24060 (17615) 17615..19840 + 2226 WP_000698737.1 P-loop NTPase fold protein -
PIB97_RS24065 (19890) 19890..20789 - 900 WP_000963206.1 nucleotide-binding protein -
PIB97_RS24070 (20779) 20779..21069 - 291 WP_000111771.1 hypothetical protein -
PIB97_RS24075 (21365) 21365..21595 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PIB97_RS24080 (21592) 21592..22008 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
PIB97_RS24085 (22170) 22170..24308 - 2139 WP_000350638.1 AAA family ATPase -
PIB97_RS24090 (24662) 24662..24919 + 258 WP_000343085.1 hypothetical protein -
PIB97_RS24095 (24919) 24919..25509 + 591 WP_000194575.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / blaCTX-M-55 / sitABCD iutA / iucD / iucC / iucB / iucA 1..111058 111058


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T268433 WP_001044768.1 NZ_CP116199:21592-22008 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT268433 WP_001261287.1 NZ_CP116199:21365-21595 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References