268431

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4400604..4401101 Replicon chromosome
Accession NZ_CP116197
Organism Escherichia coli strain DETEC-C31

Toxin (Protein)


Gene name ghoT Uniprot ID A0A163EQM5
Locus tag PIB97_RS21045 Protein ID WP_001672275.1
Coordinates 4400604..4400777 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag PIB97_RS21050 Protein ID WP_000398619.1
Coordinates 4400805..4401101 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB97_RS21035 (4397274) 4397274..4398731 + 1458 WP_021557456.1 dipeptide/tripeptide permease DtpC -
PIB97_RS21040 (4398968) 4398968..4400485 + 1518 WP_001295074.1 lysine--tRNA ligase -
PIB97_RS21045 (4400604) 4400604..4400777 - 174 WP_001672275.1 type V toxin-antitoxin system toxin GhoT Toxin
PIB97_RS21050 (4400805) 4400805..4401101 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PIB97_RS21055 (4401328) 4401328..4401600 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
PIB97_RS21060 (4401612) 4401612..4401842 - 231 WP_021557455.1 4Fe-4S mono-cluster protein YjdI -
PIB97_RS21065 (4402023) 4402023..4403654 + 1632 WP_001216477.1 sensor histidine kinase -
PIB97_RS21070 (4403651) 4403651..4404370 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4376382..4401101 24719


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6569.09 Da        Isoelectric Point: 10.2288

>T268431 WP_001672275.1 NZ_CP116197:c4400777-4400604 [Escherichia coli]
MALFSKILIFYVIGVNISFIIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT268431 WP_000398619.1 NZ_CP116197:c4401101-4400805 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A163EQM5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References