Detailed information of TA system TA026843

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1384848..1385407
• Replicon: chromosome
• Accession: NC_017522
• Organism: Mycobacterium tuberculosis CCDC5180

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: CCDC5180_RS06630
• Protein ID: WP_003898789.1
• Coordinates: 1384848..1385141 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: CCDC5180_RS06635
• Protein ID: WP_003406322.1
• Coordinates: 1385138..1385407 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCDC5180_RS06605	1380441..1380701	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
CCDC5180_RS06610	1380698..1381129	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
CCDC5180_RS06615	1381152..1382840	-	1689	WP_014584734.1	PE family protein	-
CCDC5180_RS06620	1383020..1383880	+	861	WP_003900301.1	hypothetical protein	-
CCDC5180_RS06625	1383961..1384791	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
CCDC5180_RS06630	1384848..1385141	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
CCDC5180_RS06635	1385138..1385407	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CCDC5180_RS06640	1385520..1389215	-	3696	WP_003406323.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
CCDC5180_RS06645	1389357..1390145	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T26843 WP_003898789.1 NC_017522:c1385141-1384848 [Mycobacterium tuberculosis CCDC5180]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T26843 NC_017522:c1385141-1384848 [Mycobacterium tuberculosis CCDC5180]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT26843 WP_003406322.1 NC_017522:c1385407-1385138 [Mycobacterium tuberculosis CCDC5180]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT26843 NC_017522:c1385407-1385138 [Mycobacterium tuberculosis CCDC5180]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2