Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4029061..4029611 Replicon chromosome
Accession NZ_CP116197
Organism Escherichia coli strain DETEC-C31

Toxin (Protein)


Gene name ccdB Uniprot ID D3H432
Locus tag PIB97_RS19210 Protein ID WP_001160975.1
Coordinates 4029061..4029375 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID D3H431
Locus tag PIB97_RS19215 Protein ID WP_000125565.1
Coordinates 4029378..4029611 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB97_RS19185 (4024736) 4024736..4026022 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
PIB97_RS19190 (4026022) 4026022..4027011 + 990 WP_021556398.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
PIB97_RS19195 (4027008) 4027008..4027829 + 822 WP_001065381.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
PIB97_RS19200 (4027832) 4027832..4028209 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
PIB97_RS19205 (4028216) 4028216..4029064 + 849 WP_021556397.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
PIB97_RS19210 (4029061) 4029061..4029375 - 315 WP_001160975.1 CcdB family protein Toxin
PIB97_RS19215 (4029378) 4029378..4029611 - 234 WP_000125565.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
PIB97_RS19220 (4029697) 4029697..4030176 - 480 WP_001487721.1 type 3 dihydrofolate reductase -
PIB97_RS19225 (4030368) 4030368..4032230 - 1863 WP_040234481.1 glutathione-regulated potassium-efflux system protein KefC -
PIB97_RS19230 (4032223) 4032223..4032753 - 531 WP_000600718.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
PIB97_RS19235 (4032864) 4032864..4034195 - 1332 WP_001183198.1 MFS transporter -
PIB97_RS19240 (4034253) 4034253..4034540 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.76 Da        Isoelectric Point: 9.8517

>T268427 WP_001160975.1 NZ_CP116197:c4029375-4029061 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8599.64 Da        Isoelectric Point: 6.9791

>AT268427 WP_000125565.1 NZ_CP116197:c4029611-4029378 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRRF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A090NGC7

References