Detailed information of TA system TA026842

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1380441..1381129
• Replicon: chromosome
• Accession: NC_017522
• Organism: Mycobacterium tuberculosis CCDC5180

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: CCDC5180_RS06610
• Protein ID: WP_003406304.1
• Coordinates: 1380698..1381129 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: CCDC5180_RS06605
• Protein ID: WP_003406302.1
• Coordinates: 1380441..1380701 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCDC5180_RS06585	1376018..1376842	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
CCDC5180_RS06590	1376847..1378028	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
CCDC5180_RS06595	1378105..1379205	-	1101	WP_003406300.1	magnesium/cobalt transporter CorA	-
CCDC5180_RS06600	1379376..1380365	+	990	WP_003406301.1	malate dehydrogenase	-
CCDC5180_RS06605	1380441..1380701	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
CCDC5180_RS06610	1380698..1381129	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
CCDC5180_RS06615	1381152..1382840	-	1689	WP_014584734.1	PE family protein	-
CCDC5180_RS06620	1383020..1383880	+	861	WP_003900301.1	hypothetical protein	-
CCDC5180_RS06625	1383961..1384791	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
CCDC5180_RS06630	1384848..1385141	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
CCDC5180_RS06635	1385138..1385407	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T26842 WP_003406304.1 NC_017522:1380698-1381129 [Mycobacterium tuberculosis CCDC5180]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T26842 NC_017522:1380698-1381129 [Mycobacterium tuberculosis CCDC5180]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT26842 WP_003406302.1 NC_017522:1380441-1380701 [Mycobacterium tuberculosis CCDC5180]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT26842 NC_017522:1380441-1380701 [Mycobacterium tuberculosis CCDC5180]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6