Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 881432..882086 Replicon chromosome
Accession NZ_CP116197
Organism Escherichia coli strain DETEC-C31

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag PIB97_RS04270 Protein ID WP_000244777.1
Coordinates 881679..882086 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PIB97_RS04265 Protein ID WP_000354046.1
Coordinates 881432..881698 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB97_RS04245 (877520) 877520..878953 - 1434 WP_271290925.1 6-phospho-beta-glucosidase BglA -
PIB97_RS04250 (878998) 878998..879309 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
PIB97_RS04255 (879473) 879473..880132 + 660 WP_000250274.1 hemolysin III family protein -
PIB97_RS04260 (880209) 880209..881189 - 981 WP_001625883.1 tRNA-modifying protein YgfZ -
PIB97_RS04265 (881432) 881432..881698 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PIB97_RS04270 (881679) 881679..882086 + 408 WP_000244777.1 protein YgfX Toxin
PIB97_RS04275 (882126) 882126..882647 - 522 WP_001055874.1 flavodoxin FldB -
PIB97_RS04280 (882759) 882759..883655 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PIB97_RS04285 (883680) 883680..884390 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PIB97_RS04290 (884396) 884396..886129 + 1734 WP_000813200.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T268415 WP_000244777.1 NZ_CP116197:881679-882086 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT268415 WP_000354046.1 NZ_CP116197:881432-881698 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References