Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3763711..3764365 Replicon chromosome
Accession NZ_CP116194
Organism Escherichia coli strain DETEC-E1005

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag PIB63_RS18335 Protein ID WP_000244781.1
Coordinates 3763711..3764118 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PIB63_RS18340 Protein ID WP_000354046.1
Coordinates 3764099..3764365 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB63_RS18315 (3759668) 3759668..3761401 - 1734 WP_000813189.1 single-stranded-DNA-specific exonuclease RecJ -
PIB63_RS18320 (3761407) 3761407..3762117 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PIB63_RS18325 (3762142) 3762142..3763038 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PIB63_RS18330 (3763150) 3763150..3763671 + 522 WP_001055874.1 flavodoxin FldB -
PIB63_RS18335 (3763711) 3763711..3764118 - 408 WP_000244781.1 protein YgfX Toxin
PIB63_RS18340 (3764099) 3764099..3764365 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PIB63_RS18345 (3764608) 3764608..3765588 + 981 WP_000886078.1 tRNA-modifying protein YgfZ -
PIB63_RS18350 (3765665) 3765665..3766324 - 660 WP_000250274.1 hemolysin III family protein -
PIB63_RS18355 (3766488) 3766488..3766799 - 312 WP_001182959.1 N(4)-acetylcytidine aminohydrolase -
PIB63_RS18360 (3766844) 3766844..3768277 + 1434 WP_001339296.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T268405 WP_000244781.1 NZ_CP116194:c3764118-3763711 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT268405 WP_000354046.1 NZ_CP116194:c3764365-3764099 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References