Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1203092..1203710 Replicon chromosome
Accession NZ_CP116194
Organism Escherichia coli strain DETEC-E1005

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIB63_RS05780 Protein ID WP_001291435.1
Coordinates 1203092..1203310 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIB63_RS05785 Protein ID WP_000344800.1
Coordinates 1203336..1203710 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB63_RS05745 (1198387) 1198387..1198959 + 573 WP_000779831.1 YbaY family lipoprotein -
PIB63_RS05750 (1198990) 1198990..1199294 - 305 Protein_1121 MGMT family protein -
PIB63_RS05760 (1199673) 1199673..1200026 + 354 WP_000878140.1 DUF1428 domain-containing protein -
PIB63_RS05765 (1200068) 1200068..1201618 - 1551 WP_001538392.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIB63_RS05770 (1201782) 1201782..1202252 - 471 WP_000136192.1 YlaC family protein -
PIB63_RS05775 (1202368) 1202368..1202919 - 552 WP_000102539.1 maltose O-acetyltransferase -
PIB63_RS05780 (1203092) 1203092..1203310 - 219 WP_001291435.1 HHA domain-containing protein Toxin
PIB63_RS05785 (1203336) 1203336..1203710 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIB63_RS05790 (1204256) 1204256..1207405 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
PIB63_RS05795 (1207428) 1207428..1208621 - 1194 WP_001538394.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T268396 WP_001291435.1 NZ_CP116194:c1203310-1203092 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT268396 WP_000344800.1 NZ_CP116194:c1203710-1203336 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References