Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 100906..101549 Replicon plasmid pDETEC3
Accession NZ_CP116192
Organism Escherichia coli strain DETEC-E1070

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag PIC72_RS24770 Protein ID WP_001034044.1
Coordinates 101133..101549 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag PIC72_RS24765 Protein ID WP_001261286.1
Coordinates 100906..101136 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC72_RS24750 (PIC72_24750) 96043..96273 + 231 WP_001261278.1 type II toxin-antitoxin system VapB family antitoxin -
PIC72_RS24755 (PIC72_24755) 96270..96686 + 417 WP_001034046.1 type II toxin-antitoxin system VapC family toxin -
PIC72_RS24760 (PIC72_24760) 96731..100525 - 3795 WP_001144732.1 hypothetical protein -
PIC72_RS24765 (PIC72_24765) 100906..101136 + 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PIC72_RS24770 (PIC72_24770) 101133..101549 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
PIC72_RS24775 (PIC72_24775) 101624..103189 + 1566 WP_001128474.1 AAA family ATPase -
PIC72_RS24780 (PIC72_24780) 103174..104196 + 1023 WP_000361402.1 helicase UvrD -
PIC72_RS24790 (PIC72_24790) 105450..106147 + 698 WP_223155668.1 IS1-like element IS1A family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mph(A) / blaTEM-1B / tet(B) / dfrA17 / sul2 / aph(3'')-Ib / aph(6)-Id senB 1..108072 108072


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15232.66 Da        Isoelectric Point: 6.8536

>T268385 WP_001034044.1 NZ_CP116192:101133-101549 [Escherichia coli]
VNKIYMLDTNICSFIMREQPEALLKHLEQSVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDAFCERLDAVLPWDRA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAACAILVTNNVREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8747.86 Da        Isoelectric Point: 4.3775

>AT268385 WP_001261286.1 NZ_CP116192:100906-101136 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLELEKADPDFMTEREDVVSDEGRVNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References