Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1203082..1203700 Replicon chromosome
Accession NZ_CP116191
Organism Escherichia coli strain DETEC-E1070

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIC72_RS05780 Protein ID WP_001291435.1
Coordinates 1203082..1203300 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIC72_RS05785 Protein ID WP_000344800.1
Coordinates 1203326..1203700 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC72_RS05745 (1198377) 1198377..1198949 + 573 WP_000779831.1 YbaY family lipoprotein -
PIC72_RS05750 (1198980) 1198980..1199284 - 305 Protein_1121 MGMT family protein -
PIC72_RS05760 (1199663) 1199663..1200016 + 354 WP_000878140.1 DUF1428 domain-containing protein -
PIC72_RS05765 (1200058) 1200058..1201608 - 1551 WP_001538392.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIC72_RS05770 (1201772) 1201772..1202242 - 471 WP_000136192.1 YlaC family protein -
PIC72_RS05775 (1202358) 1202358..1202909 - 552 WP_000102539.1 maltose O-acetyltransferase -
PIC72_RS05780 (1203082) 1203082..1203300 - 219 WP_001291435.1 HHA domain-containing protein Toxin
PIC72_RS05785 (1203326) 1203326..1203700 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIC72_RS05790 (1204246) 1204246..1207395 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
PIC72_RS05795 (1207418) 1207418..1208611 - 1194 WP_001538394.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T268369 WP_001291435.1 NZ_CP116191:c1203300-1203082 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT268369 WP_000344800.1 NZ_CP116191:c1203700-1203326 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References