Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4324657..4325252 Replicon chromosome
Accession NZ_CP116188
Organism Escherichia coli strain DETEC-E223

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag PIC88_RS21180 Protein ID WP_000239579.1
Coordinates 4324657..4325007 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag PIC88_RS21185 Protein ID WP_001223208.1
Coordinates 4325001..4325252 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC88_RS21160 (4320103) 4320103..4321125 - 1023 WP_001295197.1 ABC transporter permease -
PIC88_RS21165 (4321139) 4321139..4322641 - 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
PIC88_RS21170 (4322781) 4322781..4323737 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
PIC88_RS21175 (4324047) 4324047..4324577 + 531 WP_000055072.1 inorganic diphosphatase -
PIC88_RS21180 (4324657) 4324657..4325007 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
PIC88_RS21185 (4325001) 4325001..4325252 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
PIC88_RS21190 (4325464) 4325464..4325805 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
PIC88_RS21195 (4325808) 4325808..4329587 - 3780 WP_000060978.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T268351 WP_000239579.1 NZ_CP116188:c4325007-4324657 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT268351 WP_001223208.1 NZ_CP116188:c4325252-4325001 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References