Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2279142..2279780 Replicon chromosome
Accession NZ_CP116188
Organism Escherichia coli strain DETEC-E223

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag PIC88_RS11265 Protein ID WP_001447010.1
Coordinates 2279142..2279318 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PIC88_RS11270 Protein ID WP_001270286.1
Coordinates 2279364..2279780 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC88_RS11245 (2274761) 2274761..2275936 - 1176 WP_001236265.1 BenE family transporter YdcO -
PIC88_RS11250 (2276028) 2276028..2276564 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
PIC88_RS11255 (2276637) 2276637..2278598 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PIC88_RS11260 (2278690) 2278690..2278920 - 231 WP_000494244.1 YncJ family protein -
PIC88_RS11265 (2279142) 2279142..2279318 + 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PIC88_RS11270 (2279364) 2279364..2279780 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PIC88_RS11275 (2279859) 2279859..2281265 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
PIC88_RS11280 (2281510) 2281510..2282655 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
PIC88_RS11285 (2282673) 2282673..2283686 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
PIC88_RS11290 (2283687) 2283687..2284628 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T268337 WP_001447010.1 NZ_CP116188:2279142-2279318 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT268337 WP_001270286.1 NZ_CP116188:2279364-2279780 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References