Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1159377..1159995 Replicon chromosome
Accession NZ_CP116188
Organism Escherichia coli strain DETEC-E223

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PIC88_RS05615 Protein ID WP_001291435.1
Coordinates 1159377..1159595 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PIC88_RS05620 Protein ID WP_000344800.1
Coordinates 1159621..1159995 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIC88_RS05580 (1154666) 1154666..1155238 + 573 WP_000779831.1 YbaY family lipoprotein -
PIC88_RS05585 (1155269) 1155269..1155580 - 312 WP_000409911.1 MGMT family protein -
PIC88_RS05595 (1155959) 1155959..1156312 + 354 WP_000878140.1 DUF1428 domain-containing protein -
PIC88_RS05600 (1156354) 1156354..1157904 - 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PIC88_RS05605 (1158068) 1158068..1158538 - 471 WP_000136192.1 YlaC family protein -
PIC88_RS05610 (1158654) 1158654..1159205 - 552 WP_000102564.1 maltose O-acetyltransferase -
PIC88_RS05615 (1159377) 1159377..1159595 - 219 WP_001291435.1 HHA domain-containing protein Toxin
PIC88_RS05620 (1159621) 1159621..1159995 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PIC88_RS05625 (1160541) 1160541..1163690 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PIC88_RS05630 (1163713) 1163713..1164906 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T268336 WP_001291435.1 NZ_CP116188:c1159595-1159377 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT268336 WP_000344800.1 NZ_CP116188:c1159995-1159621 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References