Detailed information of TA system TA268317

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3784095..3785784
• Replicon: chromosome
• Accession: NZ_CP116181
• Organism: Escherichia coli strain DETEC-E480

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: PIB86_RS18620
• Protein ID: WP_000365807.1
• Coordinates: 3784095..3785015 (-)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: PIB86_RS18625
• Protein ID: WP_001295795.1
• Coordinates: 3785002..3785784 (-)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PIB86_RS18580 (3779568)	3779568..3780278	+	711	WP_001295798.1	fimbrial chaperone EcpE	-
PIB86_RS18585 (3780585)	3780585..3780914	+	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
PIB86_RS18590 (3780926)	3780926..3781092	-	167	Protein_3651	tail fiber assembly protein	-
PIB86_RS18595 (3781163)	3781163..3781777	-	615	WP_001019923.1	YagU family protein	-
PIB86_RS18600 (3781992)	3781992..3782177	-	186	WP_000146240.1	hypothetical protein	-
PIB86_RS18605 (3782226)	3782226..3782384	+	159	Protein_3654	integrase	-
PIB86_RS18610 (3782611)	3782611..3782946	+	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
PIB86_RS18615 (3783154)	3783154..3783930	+	777	WP_000171155.1	site-specific integrase	-
PIB86_RS18620 (3784095)	3784095..3785015	-	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
PIB86_RS18625 (3785002)	3785002..3785784	-	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
PIB86_RS18630 (3786068)	3786068..3789166	+	3099	WP_000673070.1	type I restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE	3743102..3792847	49745

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T268317 WP_000365807.1 NZ_CP116181:c3785015-3784095 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT268317 WP_001295795.1 NZ_CP116181:c3785784-3785002 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0